European Journal of Rheumatology
Case based Review

A pediatric case of SAPHO-CNO syndrome with clinical correlation between cutaneous and osteoarticular features

1.

Department of Dermatology, Royal Victoria Hospital, Belfast, Northern Ireland, UK

2.

Department of Paediatric Rheumatology, Musgrave Park Hospital, Belfast, Northern Ireland, UK

3.

Department of Dermatology, Antrim Area Hospital, Antrim, Northern Ireland, UK

Eur J Rheumatol 2020; 7: 195-198
DOI: 10.5152/eurjrheum.2020.20026
Read: 61 Downloads: 34 Published: 07 September 2020

Synovitis acne pustulosis hyperostosis osteitis (SAPHO) and chronic nonbacterial osteomyelitis (CNO) represent overlapping osteoarticular autoinflammatory syndromes, with a minority displaying neutrophilic skin features at the time of diagnosis. The pathophysiological link and chronological timeframe between skin and osteoarticular findings remain ambiguous, which in turn can manifest in diagnostic delay. We present a rare pediatric case of SAPHO-CNO with a clear association between cutaneous and osteoarticular symptoms, treated with nonsteroidal anti-inflammatory medications, corticosteroids, and intravenous pamidronate. By raising physician awareness of these syndromes, we hope that appropriate management will be initiated in a more timely fashion avoiding unnecessary investigations and treatment.

Cite this article as: Campbell V, Jackson P, Devereux C. A pediatric case of SAPHO-CNO syndrome with clinical correlation between cutaneous and osteoarticular features. Eur J Rheumatol 2020; 7(4): 195-8.

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ISSN2147-9720 EISSN 2148-4279