European Journal of Rheumatology
Case based Review

Bone marrow involvement: Atypical presentation of early-onset childhood sarcoidosis

1.

Department of Paediatrics, Government Medical College, Nagpur, Maharashtra, India

Eur J Rheumatol 2020; 7: 190-194
DOI: 10.5152/eurjrheum.2020.20076
Read: 113 Downloads: 41 Published: 08 September 2020

Childhood sarcoidosis is a chronic multisystemic, non-caseating granulomatous disease of unknown etiology. Early-onset disease classically presents with a triad of skin rash, uveitis, and arthritis, but bone marrow involvement is rare. We report a 9-1/2- year old Indian female child who presented with bleeding manifestation, skin rash, uveitis, and arthritis. Bone marrow biopsy showed multiple non-necrotizing granulomas comprising epithelioid cells, mature lymphocytes, and multinucleated giant cells with few eosinophils in the background, with negative staining for acid-fast bacilli or fungi. She was treated successfully with oral prednisolone. This is the first report of an early-onset childhood sarcoidosis with bone marrow involvement from India.

Cite this article as: Meshram RM, Gajimwar VS, Gholap S, Jhanwar M. Bone marrow involvement: atypical presentation of early-onset childhood sarcoidosis. Eur J Rheumatol 2020; 7(4): 190-4.

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ISSN2147-9720 EISSN 2148-4279