European Journal of Rheumatology
Original Article

Oral ulcer activity in Behcet’s disease: Poor medication adherence is an underestimated risk factor

1.

Department of Health Management, Marmara University School of Health Sciences, İstanbul, Turkey

2.

Department of Rheumatology, Marmara University School of Medicine, İstanbul, Turkey

3.

Department of Dermatology, Marmara University School of Medicine, İstanbul, Turkey

Eur J Rheumatol 2017; 4: 109-112
DOI: 10.5152/eurjrheum.2017.160094
Read: 183 Downloads: 39 Published: 03 September 2019

Abstract

Objective: The aim of this study was to evaluate the relationship between oral ulcer activity and medication adherence according to gender in Behçet’s disease (BD) patients.

 

Material and Methods: The study group included 330 BD patients (F/M: 167/163, mean age: 38.5±10.5 years). Oral ulcer activity and medication adherence were evaluated in the previous month. Medication adherence was evaluated using the 8-item Morisky Medication Adherence Scale (MMAS-8) having a score range of “0” to “8” with high scores indicating better adherence. Low adherence was defined as <6 points on MMAS-8.

 

Results: Over half of the group had active oral ulcers (n=219, 66.4%) within the month preceding the visit. The number of oral ulcers was significantly higher in female patients with low medication adherence (2.39±3.24) than in the rest of the female group (1.28±2.05; p=0.023). Although a similar trend was also observed in male patients (2.14±3.3 vs. 1.81±2.31), a significant relationship was not observed (p=0.89). The frequency of medication intake per day was lower in patients with high medication adherence than in the rest of the study group (p=0.04).

 

Conclusion: Low medication adherence is a hidden risk factor in the management of BD. Poor adherence was associated with oral ulcer activity in female BD patients.

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ISSN2147-9720 EISSN 2148-4279