European Journal of Rheumatology
Original Article

Efficacy of extracorporeal shockwave therapy and lowintensity pulsed ultrasound in a rat knee osteoarthritis model: A randomized controlled trial

1.

Physical Rehabilitation Medicine Clinic , S.B Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

2.

Department of Neurology, S.B.Ü Gülhane Training and Research Hospital, Ankara, Turkey

3.

Department of Physical Rhabilitation Medicine, S.B.Ü Gülhane Training and Research Hospital Ankara, Turkey

Eur J Rheumatol 2017; 4: 104-108
DOI: 10.5152/eurjrheum.2017.160089
Read: 2590 Downloads: 1927 Published: 03 September 2019

Abstract

Objective: This study aims to assess the efficacy of extracorporeal shockwave therapy (ESWT) and low-intensity pulsed ultrasound (LIPUS) on osteoarthritic rat knees.

 

Material and Methods: Twenty-four rats were divided into 3 groups: group 1-control (n=8), group 2-LIPUS (n=8) and group 3-ESWT (n=8). Cartilage degeneration was provided using mono-iodo-asetate (MIA). One milligram of MIA was delivered to the right knees in group 1 and both knees in group 2 and 3. A 0.09% saline solution was delivered to the left knees in group 1 for control. Twenty-four hours after the delivery, ESWT was applied once on the right knees in the group 2 rats to the medial tibia plateu with a 1 Hz frequency and 800 impulses. LIPUS was applied to the right knees in the group 2 rats to the medial tibia plateu with a 3 mHz frequency and 40 mW/cm2 intensity for 20 minutes over a period of 15 days. Pain scores were measured with a knee bend test. Bone mineral density measurements and scintigraphic bone scans were performed. Histopathological examination was done using a modified Mankin scale.

 

Results: There was no difference among the right knee subchondral bone osteoblastic activities (p>0.05). The left knee osteoblastic activities in the LIPUS and extracorporeal shockwave therapy (ESWT) groups were higher than those in the control group (p<0.05), but there was no difference between the LIPUS and ESWT groups. There was no difference among the groups for both knee subchondral bone BMD values (p>0.05). The modified Mankin scores of both the right and left knees of the ESWT and LIPUS groups were lower than those of the control group (p<0.05), but there was no difference between the ESWT and LIPUS groups. The pain scores of both knees of the ESWT and LIPUS groups at day 7 were higher than those of the control group (p<0.05), but there was no difference between the ESWT and LIPUS groups. There was no difference among the pain scores of the right knees at day 14 (p<0.05).

 

Conclusion: ESWT and LIPUS have systemic proliferative and regenerative effects on cartilage and tissue. 

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EISSN 2148-4279