Case Report

Acute Foot Drop in the Initial Presentation of Systemic Lupus Erythematosus

Volume 13 · Issue 2 Publish Date: July 8, 2026
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Matthew Gabriel ORCID
Northwestern Medicine Marianjoy Rehabilitation Hospital, Physical Medicine and Rehab, Wheaton, IL, United States
Ximena Chavez ORCID
Endeavor Health Rheumatology, Evanston, IL, United States
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Abstract

The case of a 20-year-old woman with newly diagnosed systemic lupus erythematosus (SLE) who developed acute foot drop secondary to mononeuritis multiplex is presented. Peripheral neuropathy etiology is broad, but in the setting of SLE, it should raise concern for vasculitis, as seen in this case with mononeuritis multiplex. Diagnosis requires an understanding of SLE pathology as seen with muscle and nerve biopsy. Prompt diagnosis and high-dose corticosteroids are critical, but pain may persist despite immunosuppression.

Cite this article as: Gabriel M, Chavez X. Acute foot drop in the initial presentation of systemic lupus erythematosus. Eur J Rheumatol. 2026, 13(2), 0008, DOI: 10.5152/eurjrheum.2026.26008.

Article Info
Published In
Journal European Journal of Rheumatology
Volume / Issue Volume 13 · Issue 2
Pages 1-3
History
Published Online July 8, 2026
Affiliations
Matthew Gabriel ORCID
Northwestern Medicine Marianjoy Rehabilitation Hospital, Physical Medicine and Rehab, Wheaton, IL, United States
Ximena Chavez ORCID
Endeavor Health Rheumatology, Evanston, IL, United States
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