Published In
European Journal of Rheumatology
Volume 13 · Issue 2
Pages: 1-2
History
Published Online: May 12, 2026
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © 2026 European Journal of Rheumatology
Ana Serrano-Combarro
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States; Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Jenna Guma
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Sergio A Jimenez
Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Fabian A Mendoza
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States; Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
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Abstract
A 74-year-old patient initially presented with rapid onset of bilateral leg swelling, leukocytosis (monocytosis and eosinophilia), hand arthritis, elevated inflammatory markers, and 20% weight loss. Extensive workup, including a bone marrow biopsy, did not show evidence of malignancy. The patient was evaluated many months after initiation of symptoms and found to have deep hardening skin and multiple joint contractures. Pictures of his forearms are shown above.
Cite this article as: Combarro AS, Guma J, Jimenez SA, Mendoza FA. The groove sign. Eur J Rheumatol. 2026, 13(2), 0079, doi: 10.5152/eurjrheum.2026.25079.
Article Info
Published In
Journal
European Journal of Rheumatology
Volume / Issue
Volume 13 · Issue 2
Pages
1-2
History
Published Online
May 12, 2026
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright
Copyright (c) 2026 European Journal of Rheumatology
Affiliations
Ana Serrano-Combarro
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States; Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Jenna Guma
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Sergio A Jimenez
Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Fabian A Mendoza
Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States; Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
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