Disease Course of Axial Spondyloarthritis in Pregnancy

Abstract

Objective: Limited information exists regarding the impact of axial spondyloarthritis (axSpA) on pregnancy compared to other chronic inflammatory disorders. Axial spondyloarthritis’s unique anatomical and inflammatory impact on pregnancy presents challenges. This study aims to assess axSpA’s progression during pregnancy.

Methods: A retrospective observational study at a private rheumatology clinic assessed axSpA’s progression during pregnancy in 80 women previously diagnosed with the condition.

Results: Onset of axSpA occurred at an average age of 23.2 years. Symptoms worsened in 29 (36.25%) patients during pregnancy, while 51 (63.7%) experienced improvement or remission. Twelve (15%) women faced conception difficulties, with a delay of over a year. Cesarean sections were performed in 42 (62.6%) cases, while 25 (37.3%) had full-term vaginal deliveries.

Conclusion: During pregnancy, there is a noticeable tendency for alterations in disease activity and symptoms experienced. This study highlights the need for better understanding and awareness of axSpA’s impact on pregnancy outcomes.

Cite this article as: Gore S, Tambe R, Raut A, Patil P. Disease course of axial spondyloarthritis in pregnancy. Eur J Rheumatol. 2026, 13, 0107, doi:10.5152/eurjrheum.2026.24107.