Published In
European Journal of Rheumatology
Volume 7 · Issue 1
Pages: S58-S66
History
Published Online: January 31, 2020
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © 2020 European Journal of Rheumatology
Florence A. Aeschlimann
Paediatric Immunology, Hematology and Rheumatology Unit, Hôpital Necker - Enfants Malades, Paris, France
Marinka Twilt
Division of Rheumatology, Department of Paediatric, Alberta Children’s Hospital, Alberta Children’s Hospital Research Institute, Alberta, Canada
Rae S. M. Yeung
Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
Aeschlimann, F. A., Twilt, M., & Yeung, R. S. M. (2020). Childhood-onset Takayasu Arteritis. European Journal of Rheumatology, 7(1), S58-S66. https://doi.org/10.5152/eurjrheum.2019.19195
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Abstract
Childhood-onset Takayasu Arteritis (cTAK) is a rare, large-vessel type of vasculitis seen in children, mainly affecting the aorta and its major branches. Clinical manifestations are often severe and arise as a result of systemic and local inflammation, along with end-organ ischemia. Disease flares are common and the disease burden is high, with a significant rate of morbidity and mortality. Recent advances in understanding the underlying disease pathobiology resulted in the use of pathway-targeting agents, such as TNF- or IL-6 inhibitors with improved disease control. Nonetheless, the prognosis often remains guarded and the accrued damage is significant. This review aims at summarizing the recent evidence and observations regarding this condition, with a focus on pediatric publications.
Cite this article as: Aeschlimann FA, Twilt M, Yeung RSM. Childhood-onset Takayasu Arteritis. Eur J Rheumatol 2020; 7(Suppl 1): S58-S66
Article Info
Published In
Journal
European Journal of Rheumatology
Volume / Issue
Volume 7 · Issue 1
Pages
S58-S66
History
Published Online
January 31, 2020
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright
Copyright (c) 2020 European Journal of Rheumatology
Affiliations
Florence A. Aeschlimann
Paediatric Immunology, Hematology and Rheumatology Unit, Hôpital Necker - Enfants Malades, Paris, France
Marinka Twilt
Division of Rheumatology, Department of Paediatric, Alberta Children’s Hospital, Alberta Children’s Hospital Research Institute, Alberta, Canada
Rae S. M. Yeung
Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
Cite this Article
Aeschlimann, F. A., Twilt, M., & Yeung, R. S. M. (2020). Childhood-onset Takayasu Arteritis. European Journal of Rheumatology, 7(1), S58-S66. https://doi.org/10.5152/eurjrheum.2019.19195
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