ISSN 2147-9720 | E-ISSN 2148-4279
Original Article
Oral ulcer activity in Behcet’s disease: Poor medication adherence is an underestimated risk factor
1 Department of Health Management, Marmara University School of Health Sciences, İstanbul, Turkey  
2 Department of Rheumatology, Marmara University School of Medicine, İstanbul, Turkey  
3 Department of Dermatology, Marmara University School of Medicine, İstanbul, Turkey  
Eur J Rheumatol 2017; 4: 109-112
DOI: 10.5152/eurjrheum.2017.160094
Key Words: Medication adherence, oral ulcer, Behçet’s disease

Objective: The aim of this study was to evaluate the relationship between oral ulcer activity and medication adherence according to gender in Behçet’s disease (BD) patients.


Material and Methods: The study group included 330 BD patients (F/M: 167/163, mean age: 38.5±10.5 years). Oral ulcer activity and medication adherence were evaluated in the previous month. Medication adherence was evaluated using the 8-item Morisky Medication Adherence Scale (MMAS-8) having a score range of “0” to “8” with high scores indicating better adherence. Low adherence was defined as <6 points on MMAS-8.


Results: Over half of the group had active oral ulcers (n=219, 66.4%) within the month preceding the visit. The number of oral ulcers was significantly higher in female patients with low medication adherence (2.39±3.24) than in the rest of the female group (1.28±2.05; p=0.023). Although a similar trend was also observed in male patients (2.14±3.3 vs. 1.81±2.31), a significant relationship was not observed (p=0.89). The frequency of medication intake per day was lower in patients with high medication adherence than in the rest of the study group (p=0.04).


Conclusion: Low medication adherence is a hidden risk factor in the management of BD. Poor adherence was associated with oral ulcer activity in female BD patients.

Key Words
Author’s Corner
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