European Journal of Rheumatology
Case Report

Successful treatment of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) with tocilizumab: a case report

1.

Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium

Eur J Rheumatol 2015; 2: 35-36
DOI: 10.5152/eurjrheumatol.2014.14053
Read: 2693 Downloads: 1138 Published: 03 September 2019

Abstract

Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory disease linked to chromosome 12p13 and, more specifically, with mutations within the tumor necrosis factor receptor superfamily, member 1A gene (TNFRSF1A gene). It is characterized by the presence of fever, abdominal pain, myalgia, arthralgia or arthritis, and skin rash.

 

In this report, we describe the case of a patient with tumor necrosis factor receptor-associated periodic syndrome (TRAPS) treated successfully with the anti-interleukin-6 (anti-IL-6) receptor monoclonal antibody tocilizumab, while treatment with anti-TNF α etanercept and infliximab had both failed.

 

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EISSN 2148-4279