European Journal of Rheumatology
Original Article

Serum sCTLA-4 levels and clinical manifestations in ankylosing spondylitis patients

1.

Department of Occupational Medicine, Hacettepe University School of Medicine, Ankara, Turkey

2.

Department of Rheumatology, Adnan Menderes University School of Medicine, Aydın, Turkey

3.

Department of Clinical Microbiology, Adnan Menderes University School of Medicine, Aydın, Turkey

Eur J Rheumatol 2018; 5: 115-117
DOI: 10.5152/eurjrheum.2018.17114
Read: 102 Downloads: 20 Published: 03 September 2019

Abstract

 

Objective: T cell abnormal activation is thought to have a main role in the etiology of ankylosing spondylitis (AS). While cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) is suppressing the immune system, in previous studies serum soluble CTLA-4 (sCTLA-4) was detected at high amounts in autoimmune disorders. We sought to evaluate the association between soluble CTLA-4 in serum and disease activity in AS patients.

 

Methods: Thirty-eight patients with AS, 28 rheumatoid arthritis (RA) patients, and 27 disease-free controls were enrolled to the study. The levels of sCTLA-4 were determined for each participant using an enzyme-linked immunosorbent assay. The erythrocyte sedimentation rate (ESR), C-reactive peptide, and demographic characteristics were documented. The data were analyzed by using relevant statistical methods.

 

Results: In comparison with RA patients and controls, patients with AS showed high sCTLA-4 levels (p<0.001). The sCTLA-4 levels did not correlate with the severity of the disease in AS patients (p=0.370). The ESR levels and Bath Ankylosing Spondylitis Disease Activity Index were correlated in AS patients (p=0.012).

 

Conclusion: We evaluated the association between the disease severity of AS and sCTLA-4. Although, the correlation was not shown, sCTLA-4 was highest in the AS group. Further studies with larger samples should be completed to attain a better understanding of the AS etiology.

 

Cite this article as: Çetintepe SP, Şentürk T, Sargın G, Aydın N. Serum sCTLA-4 levels and clinical manifestations in ankylosing spondylitis patients. Eur J Rheumatol 2018; 5: 115-7.

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ISSN2147-9720 EISSN 2148-4279