European Journal of Rheumatology
Invited Review

Pediatric Behçet’s disease - clinical aspects and current concepts

1.

Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey

2.

Department of Pediatric Rheumatology, İstanbul University, İstanbul School of Medicine, İstanbul, Turkey

Eur J Rheumatol 2020; 7: Supplement S38-S47
DOI: 10.5152/eurjrheum.2019.19121
Read: 211 Downloads: 154 Published: 31 January 2020

Behçet’s Disease was first described by a Turkish dermatologist, Hulusi Behçet, in 1937 as a triple symptom complex; aphthous stomatitis, genital ulcers, and uveitis. Today, in light of current trials and experiments, we know that the disease may have a wider involvement with a multisystemic recurrent course, causing significant morbidity and mortality. However, there are still unanswered questions, particularly about Pediatric Behçet’s Disease. Although several immunological and genetic associations have been demonstrated, the real etiologic mechanism of the disease is unclear. The diagnosis is difficult due to its rarity in childhood, the lack of validation of the diagnostic criteria obtained from adult studies, and the inadequacy of large case-controlled studies. Also, the management is challenging and controversial due to the various geographic distribution of clinical spectrum. New therapeutic options under development in light of pathogenetic hypothesis seem to be promising.

Cite this article as: Yıldız M, Köker O, Adrovic A, Şahin S, Barut K, Kasapçopur Ö. Pediatric Behçet’s disease - clinical aspects and current concepts. Eur J Rheumatol 2020; 7(Suppl 1): S38-S47.

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ISSN2147-9720 EISSN 2148-4279