European Journal of Rheumatology
Case Report

Novel case of anti-synthetase syndrome


Department of Internal Medicine, SSM Health St Mary’s Hospital, St. Louis, Missouri, USA


Department of Rheumatology, SSM Health St Mary’s Hospital, St. Louis, Missouri, USA

Eur J Rheumatol 2018; 5: 275-277
DOI: 10.5152/eurjrheum.2018.17167
Read: 2754 Downloads: 1043 Published: 03 September 2019



Anti-synthetase syndrome (AS) is a heterogeneous group of systemic autoimmune diseases associated with anti-aminoacyl-transfer RNA synthetases. These inflammatory myopathies present with a constellation of symptoms including myositis, arthritis, Raynaud’s phenomenon, and interstitial lung disease (ILD). We present a novel case of a 44-year-old female, who presented with Anti-OJ AS with severe myopathy and rhabdomyolysis without evidence of ILD, which, in our literature review and to the best of our knowledge, has not been previously reported. Furthermore, our patient was initially misdiagnosed, highlighting the paucity of cases and physicians’ unfamiliarity with this disease. After her diagnosis was confirmed, the patient was successfully treated with high-dose steroids and transitioned to azathioprine, and she continues to do well. This case report emphasizes a novel presentation of the rarely diagnosed AS. We also discuss the significant overlap between the inflammatory myopathies and consolidate relevant pathophysiology and current trends in the management of this disease.


Cite this article as: Kapoor A, Vaidyan P, Jalil B, Uppaluri C. Novel case of anti-synthetase syndrome. Eur J Rheumatol 2018; 5: 275-7

EISSN 2148-4279