European Journal of Rheumatology
Original Article

Clinical and demographic aspects of Paget disease of bone: A multicentric study from Turkey

1.

Department of Endocrinology and Metabolism, Marmara University School of Medicine, İstanbul, Turkey

2.

Department of Endocrinology and Metabolism, Trakya University School of Medicine, Edirne, Turkey

3.

Department of Endocrinology and Metabolism, Ege University School of Medicine, İzmir, Turkey

4.

Department of Endocrinology and Metabolism, Dokuz Eylül University School of Medicine, İzmir, Turkey

5.

Department of Endocrinology and Metabolism, Necmettin Erbakan University School of Medicine, Konya, Turkey

6.

Department of Endocrinology and Metabolism, Celal Bayar University School of Medicine, Manisa, Turkey

7.

Department of Endocrinology and Metabolism, Yeditepe University School of Medicine, İstanbul, Turkey

8.

Department of Endocrinology and Metabolism, Yeni Yuzyıl University School of Medicine, İstanbul, Turkey

9.

Department of Endocrinology and Metabolism, Health Sciences University School of Medicine, Abdulhamid Han Hospital, İstanbul, Turkey

10.

Department of Endocrinology and Metabolism, Selçuk University School of Medicine, Konya, Turkey

11.

Department of Endocrinology and Metabolism, Ondokuz Mayıs University School of Medicine, Samsun, Turkey

12.

Department of Geriatrics, İzmir Ege University School of Medicine, İzmir, Turkey

13.

Department of Endocrinology and Metabolism, Kocaeli University School of Medicine, Kocaeli, Turkey

14.

Department of Endocrinology and Metabolism, Health Sciences University School of Medicine, Sadi Konuk Hospital, İstanbul, Turkey

15.

Department of Endocrinology and Metabolism, Health Sciences University School of Medicine, Fatih Sultan Mehmet Hospital, İstanbul, Turkey

16.

Department of Endocrinology and Metabolism, Başkent University School of Medicine, Adana Hospital, Adana, Turkey

17.

Department of Endocrinology and Metabolism, Uşak University School of Medicine, Uşak, Turkey

18.

Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey

19.

Department of Endocrinology and Metabolism, Koç University School of Medicine, İstanbul, Turkey

20.

Hacettepe University Faculty of Medicine Section of Endocrinology and Metabolism, Ankara, Turkey

Eur J Rheumatol 2021; 8: 156-161
DOI: 10.5152/eurjrheum.2020.20139
Read: 112 Downloads: 35 Published: 03 December 2020

Objective: Paget disease of bone (PDB) is a metabolic bone disease that has been rarely reported in the Eastern countries. This study aimed to evaluate the clinical and demographic characteristics of patients with PDB followed up at endocrinology clinics in Turkey.

Methods: An invitation was sent to tertiary endocrinology clinics to complete a survey on the demographic, clinical, radiological, and laboratory parameters, as well as treatment modalities of patients with PDB. This study enrolled clinically and radiologically proven 185 patients with PDB from 18 endocrinology centers based in 10 cities of Turkey.

Results: This cohort of PDB had female preponderance (women/men: 105/80) with a mean age, during diagnosis, of 57±10 years. Most of the patients (59.6%) were symptomatic at diagnosis. Bone pain and headache were the predominant clinical symptoms. Polyostotic disease was observed in 67.5% (n=125) of patients. Frequently affected bones were skull (41.6%), pelvis (53.5%), spine (41%), and femur (25.4%). Moreover, 17 patients with skull involvement had hearing loss. Mean serum alkaline phosphatase (ALP) level (552±652 IU/L; range: 280-5762 IU/L) was over the normal reference cutoff with normal serum calcium levels. Intravenous bisphosphonates (zoledronic acid, 5 mg; pamidronate, 60-90 mg) were the most used drugs (75%) for the treatment of PDB. Most of the patients (87.1%) treated with intravenous bisphosphonates responded well, with a decrease in serum ALP level (117±114 IU/L) in the 12th month of therapy. Furthermore, 16 patients relapsed after the second year of therapy; 3 patients did not respond to the initial intravenous bisphosphonate treatment.

Conclusion: The patients with PDB followed up by endocrinology clinics of Turkey exhibited polyostotic disease with classical clinical, radiological, and biochemical features and women’s predominance with good response to intravenous bisphosphonate therapy.

Cite this article as: Gogas Yavuz D, Aytürk S, Çetinkalp Ş, Bayraktar F, Kulaksızoğlu M, Hekimsoy Z, et al. Clinical and demographic aspects of Paget disease of bone: A multicentric study from Turkey. Eur J Rheumatol 2021; 8(3): 156-61.

Files
ISSN 2147-9720 EISSN 2148-4279