European Journal of Rheumatology
Invited Review

Childhood-onset Takayasu Arteritis


Paediatric Immunology, Hematology and Rheumatology Unit, Hôpital Necker - Enfants Malades, Paris, France


Division of Paediatrics, Kantonsspital Winterthur, Winterthur, Switzerland


Division of Rheumatology, Department of Paediatric, Alberta Children’s Hospital, Alberta Children’s Hospital Research Institute, Alberta, Canada


Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada


Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada


Department of Immunology, University of Toronto, Toronto, Ontario, Canada

Eur J Rheumatol 2020; 7: Supplement S58-S66
DOI: 10.5152/eurjrheum.2019.19195
Read: 164 Downloads: 125 Published: 31 January 2020

Childhood-onset Takayasu Arteritis (cTAK) is a rare, large-vessel type of vasculitis seen in children, mainly affecting the aorta and its major branches. Clinical manifestations are often severe and arise as a result of systemic and local inflammation, along with end-organ ischemia. Disease flares are common and the disease burden is high, with a significant rate of morbidity and mortality. Recent advances in understanding the underlying disease pathobiology resulted in the use of pathway-targeting agents, such as TNF- or IL-6 inhibitors with improved disease control. Nonetheless, the prognosis often remains guarded and the accrued damage is significant. This review aims at summarizing the recent evidence and observations regarding this condition, with a focus on pediatric publications.

Cite this article as: Aeschlimann FA, Twilt M, Yeung RSM. Childhood-onset Takayasu Arteritis. Eur J Rheumatol 2020; 7(Suppl 1): S58-S66

ISSN2147-9720 EISSN 2148-4279