European Journal of Rheumatology
Original Article

Autonomic functions in acrocyanosis assessed by heart rate variability


Department of Rheumatology, Gülhane Military Medical Academy, Ankara, Turkey


Department of Cardiology, Gülhane Military Medical Academy, Ankara, Turkey


Department of Rheumatology, Gülhane School of Medicine, Ankara, Turkey


Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey

Eur J Rheumatol 2014; 1: 18-20
DOI: 10.5152/eurjrheum.2014.005
Read: 2449 Downloads: 2124 Published: 03 September 2019


Objective: To evaluate the autonomic activity of patients with acrocyanosis by using heart rate variability indices.


Material and Methods: The study group consisted of 24 patients with acrocyanosis and the control group contained 22 sex- and age-matched healthy subjects. All subjects underwent 24-hour Holter monitoring. Among the heart rate variability (HRV) parameters, time-domain and frequency-domain indices were analysed.


Results: The time-domain indices of HRV indicating global autonomic functions were found to be increased, and indices indicating parasympathetic activity showed a significant decrease in the patient group. Power-spectral analysis of HRV revealed that the low frequency and high frequency power were higher in the patient group than in controls. However, the ratio of Low Frequency/High Frequency was found to be lower in the patient group than in controls.


Conclusion: In acrocyanosis, both sympathetic and parasympathetic systems seem to be disrupted. Therefore, we may conclude that acrocyanosis may be resulted of systemic autonomic imbalance rather than pure sympathetic over-activation. Also, these results suggest that acrocyanosis is not a localised disorder; on the contrary, it is associated with various abnormalities of the systemic autonomic nervous system. 


EISSN 2148-4279