European Journal of Rheumatology
Original Article

Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus

1.

Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico

2.

Department of Biology, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico

Eur J Rheumatol 2018; 5: 244-248
DOI: 10.5152/eurjrheum.2018.18074
Read: 16 Downloads: 1 Published: 03 September 2019

Abstract

 

Objective: The soluble triggering receptor expressed on myeloid cells (TREM-1)-like transcript 1 (sTLT-1) has a modulatory effect on the activation of TREM-1. We compared plasma sTLT-1 levels between patients with systemic lupus erythematosus (SLE) and healthy individuals and determined the association between sTLT-1 levels and clinical features and patient-reported outcomes (PROs) among patients with lupus.


Methods
: An unmatched case-control study was conducted in 46 patients with SLE and 28 healthy subjects. sTLT-1 plasma levels were determined using enzyme-linked immunosorbent assay. Demographic factors, SLE manifestations, comorbidities, pharmacologic profile, disease activity (per SLAM-R), damage accrual, and PROs (as per Lupus Patient-Reported Outcome [LupusPRO]) were studied.


Results
: Patients with SLE were found to have lower sTLT-1 levels compared with healthy individuals (9.0±7.2 vs. 18.6±22.3 pg/mL, p=0.008). Among patients with SLE, higher sTLT-1 levels were found in those taking corticosteroids (11.1±8.8 vs. 6.9±4.6 pg/mL, p=0.014). Significant correlations were found for the cognition (r=-0.442, p=0.027) and desires/goals (r=0.435, p=0.030) domains of LupusPRO. A tendency was observed between sTLT-1 levels and the SLAM-R (r=-0.278, p=0.064) and the lupus symptoms (r=-0.388, p=0.055) and physical health (r=-0.382, p=0.060) domains of LupusPRO.


Conclusion
: Compared with healthy individuals, sTLT-1 levels were significantly lower in patients with SLE. Among patients with SLE, correlations were observed for some domains of LupusPRO. Given that sTLT-1 has anti-inflammatory properties, the deficiency of this protein could play an important role in the pathogenesis of SLE.


Cite this article as
: Vázquez-Otero I, Rodríguez-Navedo Y, Vilá-Rivera K, Nieves-Plaza M, Morales-Ortiz J, Washington AV, et al. Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus. Eur J Rheumatol 2018; 5: 244-8.

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ISSN2147-9720 EISSN 2148-4279