European Journal of Rheumatology
Original Article

Anti-TNF treatment in ankylosing spondylitis patients with chronic kidney disease: Is it effective and safe?

1.

Division of Rheumatology, Uludağ University School of Medicine, Bursa, Turkey

2.

Division of Biostatistics, Uludağ University School of Medicine, Bursa, Turkey

Eur J Rheumatol 2022; 9: 68-74
DOI: 10.5152/eurjrheum.2022.21099
Read: 303 Downloads: 78 Published: 01 April 2022

Objective: This study aims to examine the efficacy and safety of the antitumor necrosis factor (TNF) drugs in ankylosing spondylitis (AS) patients with chronic kidney disease.

Methods: In this study, 24 male patients with a glomerular filtration rate (GFR) of <60 mL min􏰁1 1.73 m􏰁2 were included among 863 patients who were followed-up once in 3 months regularly from 2010 to 2018years. Twenty-four patients were chosen for the control group among 420 male patients whose renal functions were normal using random sampling. We examined C-reactive protein, erythro- cyte sedimentation rate, serum creatinine, and GFR values, and also the measurements of Bath Anky- losing Spondylitis Disease Activity Index (BASDAI) were recorded at the beginning of the treatment with anti-TNF agents and in the 3rd, 6th, 9th, 12th, and final visit months.

Results: Eleven (45.9%) of the patients included in the study were in the routine dialysis program. The initial anti-TNF treatments were etanercept (62.5%), infliximab (16.7%), adalimumab (16.7%), and goli- mumab (4.1%). Treatment was effective in 22 (91.7%) of the patients. When the values of the two groups’ patients were compared at the beginning of the treatment, there was a substantial reduction regarding BASDAI (P < .001). Pleural effusion, infective endocarditis, septic arthritis, and prosthesis infection were major side effects (n 1⁄4 4). The mortality rate of the 24 patients was 29.2% (n 1⁄4 7).

Conclusion: This study demonstrated that anti-TNF drug treatment is effective and safe in patients with AS who have chronic kidney disease.

Cite this article as: Co􏰀şkun BN, Yağız ,Çorabay SG, Pehlivan Y, Dalkılıç E. Anti- TNF treatment in ankylosing spondylitis patients with chronic kidney disease: Is it effective and safe? Eur J Rheumatol.2022;9(2):68-74.

 

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