ISSN 2147-9720 | E-ISSN 2148-4279
Original Article
Clinical characteristics and prognosis of Neuro-Behçet’s disease
1 Department of Neurology, Ankara University School of Medicine, İbni Sina Hospital, Ankara, Turkey  
2 Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark  
Eur J Rheumatol ; : -
DOI: 10.5152/eurjrheum.2018.18033
Key Words: Neuro-Behçet’s disease, neurological involvement, functional system involvement, cranial MRI lesions, prognosis
Abstract

Objective: Neuro-Behçet’s disease (NBD) is a rare manifestation of Behçet’s disease (BD) and may cause severe disability. The aim of this study was to evaluate the treatment response in patients with NBD and to investigate the parameters that may influence the prognosis of the disease in patients with severe to mild-moderate disability.


Methods
: The files of 60 patients admitted to our outpatient clinic for NBD between January 2007 and June 2014 were retrospectively reviewed. We compared the BD duration, time to NBD, NBD type and course, clinical findings of BD, functional neurological system involvement, localization of lesions on brain MRI, and all the medications between the severe and mild-moderate disability groups.


Results
: The mean time to the onset of NBD was significantly longer (17.8±4.6 years) and the mean age was significantly higher (50.25±9.1 years) in patients with severe disability than in those with mild-moderate disability (7.5±8.0 years and 37.5±10.9 years; p=0.01 and p=0.03, respectively). Moreover, hemispheric involvement was significantly associated with severe disability (p=0.006). No difference was found with regard toother investigated parameters between the groups.


Conclusion
: We believe that severe neurological disability may be associated with older age at the onset of NBD or longer time to NBD and hemispheric lesions on brain MRI. However, our results should be cautiously evaluated with further research.


Cite this article as
: Sorgun MH, Kural MA, Yücesan C. Clinical characteristics and prognosis of Neuro-Behçet’s disease. Eur J Rheumatol DOI: 10.5152/eurjrheum.2018.18033

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