ISSN 2147-9720 | E-ISSN 2148-4279
Original Article
Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease
1 Department of Medical Biology, Gaziosmanpaşa University School of Medicine, Tokat, Turkey  
2 Department of Medical Genetics, Hitit University School of Medicine, Çorum, Turkey  
3 Department of Opthalmology, Gaziosmanpaşa University School of Medicine, Tokat, Turkey  
4 Department of Biostatistics, Gaziosmanpaşa University School of Medicine, Tokat, Turkey  
Eur J Rheumatol 2018; 5: 27-31
DOI: 10.5152/eurjrheum.2017.16102
Key Words: Behçet's disease, interleukin 1 receptor antagonist, variable number tandem repeat
Abstract

Objective: Behçet’s disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.

 

Methods: One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed using Statistical Package for Social Sciences (SPSS) 22.0 (p<0.05).

 

Results: The genotype distribution and allele frequencies of the IL-1Ra VNTR variant did not differ significantly between the patients and the controls (p>0.05). The frequency of the a1/a1, a1/a2 genotypes and a1, a2 alleles were the most common both in patients and healthy controls (p=0.37, p=0.26, and p=0.53, respectively). Also, no statistically significant difference was found between the IL-1Ra VNTR variant genotypes and clinical characteristics (p>0.05).

 

Conclusion: The results of this study do not support an association between the IL-1Ra VNTR variant and the risk of BD in a Turkish population. However, further studies of this variant with larger sample sizes and different ethnicities are required for confirmation. 

 

Cite this article as: Dursun G, Nursal AF, Deniz Demir H, Karakuş N, Demir O, Yiğit S. Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease. Eur J Rheumatol 2018; 5: 27-31.

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