ISSN 2147-9720 | E-ISSN 2148-4279
Original Article
The relationship of serum endocan levels and anti-TNF-alpha therapy in patients with ankylosing spondylitis
1 Department of Nutrition and Dietetic, Gazi University, Ankara, Turkey.; Department of Health Sciences, California Baptist University, Riverside, California, USA  
2 Department of Nutrition and Dietetic, Gazi University, Ankara,Turkey.  
Eur J Rheumatol 2018; 5: 1-4
DOI: 10.5152/eurjrheum.2017.17287
Key Words: Anti-TNF-alpha treatment, ankylosing spondylitis, endocan
Abstract

 

Objective: Endocan is a marker for vascular pathogenesis and important mediator of angiogenesis that strongly associates with inflammation and vascular diseases. Growing evidence suggest that inflammatory cytokine tumor necrosis factor (TNF-alpha) plays a role in its regulation and secretion, whereas TNF-alpha inhibitors may have the opposite influence. The aim of this research is to investigate the association between serum endocan and anti-TNF-alpha drug treatment in patients with ankylosing spondylitis (AS).

 

Methods: Serum endocan levels were analyzed in 42 patients with AS under anti-TNF-alpha usage. Control group consisted of 37 patients with AS who are not receiving anti-TNF drugs. Endocan is analyzed using ESM-1 ELISA kits. The blood glucose and lipid measurements of patients were also assessed.

 

Results: There was no significant change in serum endocan levels among groups. The total cholesterol, triglyceride, and LDL-C levels were higher in patients receiving anti-TNF-alpha; however, differences were not significant. There was no significant correlation between serum endocan levels and blood lipid measurements.

 

Conclusion: Anti-TNF-alpha treatment does not affect serum endocan levels in patients with AS. This research has been first to evaluate the relationship between serum endocan and anti-TNF-alpha therapy in AS. Future studies are necessary to verify the exact role of anti-TNF-alpha therapy on serum endocan levels in patients with AS.

 

Cite this article as: Kadayıfçı FZ, Gezmen Karadağ M. The relationship of serum endocan levels and anti-TNF-alpha therapy in patients with ankylosing spondylitis. Eur J Rheumatol 2018; 5: 1-4.

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