ISSN 2147-9720 | E-ISSN 2148-4279
Original Article
Serum hepcidin level and rheumatoid arthritis disease activity
1 Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran  
2 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran  
3 Student Research Committee, Mashhad University of Medical Sciences School of Medicine, Mashhad, Iran  
Eur J Rheumatol 2019; 6: 76-80
DOI: 10.5152/eurjrheum.2018.18114
Key Words: Rheumatoid arthritis, anemia, anemia of chronic disease, hepcidin, inflammation, DAS28-ESR
Abstract

Objective: The present study aimed to determine the relationship between the serum hepcidin level and disease activity in patients with rheumatoid arthritis (RA).

 

Methods: This study was conducted on 80 patients with RA (36 cases with anemia of chronic disease [ACD] and 44 patients without ACD). Disease activity was measured by the 28-joint Disease Activity Score based on the erythrocyte sedimentation rate (DAS28-ESR). According to the DAS28-ESR score, 52 and 28 cases were categorized as inactive to moderately active RA (DAS28-ESR≤5.1) and highly active RA (DAS28-ESR>5.1), respectively. In addition, the serum hepcidin level was evaluated in all patients to determine its correlation with the DAS28-ESR score.

 

Results: There was no significant difference between the RA with ACD and RA without ACD groups in terms of the median (interquartile range) hepcidin level (1207 [985.2] vs. 923.8 [677.3] ng/mL; P=0.57). Likewise, no significant difference was observed between the active RA and inactive to moderately active RA groups in this regard (1131.8 [991.3] vs. 1090.9 [631.4] ng/mL; P=0.53).

 

Conclusion: Hepcidin has no association with disease activity in RA. Therefore, it is not necessary to measure hepcidin to determine the RA activity.

 

Cite this article as: Sahebari M, Rezaieyazdi Z, Hashemy SI, Khorasani S, Shahgordi S, Alizadeh MK, et al. Serum hepcidin level and rheumatoid arthritis disease activity. Eur J Rheumatol 2019; 6(2): 73-7.

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