ISSN 2147-9720 | E-ISSN 2148-4279
Original Article
Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus
1 Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico  
2 Department of Biology, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico  
Eur J Rheumatol 2018; 5: 244-248
DOI: 10.5152/eurjrheum.2018.18074
Key Words: Systemic lupus erythematosus, soluble TREM-like transcriptase 1, clinical manifestations, disease activity, disease damage, patient-reported outcomes
Abstract

 

Objective: The soluble triggering receptor expressed on myeloid cells (TREM-1)-like transcript 1 (sTLT-1) has a modulatory effect on the activation of TREM-1. We compared plasma sTLT-1 levels between patients with systemic lupus erythematosus (SLE) and healthy individuals and determined the association between sTLT-1 levels and clinical features and patient-reported outcomes (PROs) among patients with lupus.


Methods
: An unmatched case-control study was conducted in 46 patients with SLE and 28 healthy subjects. sTLT-1 plasma levels were determined using enzyme-linked immunosorbent assay. Demographic factors, SLE manifestations, comorbidities, pharmacologic profile, disease activity (per SLAM-R), damage accrual, and PROs (as per Lupus Patient-Reported Outcome [LupusPRO]) were studied.


Results
: Patients with SLE were found to have lower sTLT-1 levels compared with healthy individuals (9.0±7.2 vs. 18.6±22.3 pg/mL, p=0.008). Among patients with SLE, higher sTLT-1 levels were found in those taking corticosteroids (11.1±8.8 vs. 6.9±4.6 pg/mL, p=0.014). Significant correlations were found for the cognition (r=-0.442, p=0.027) and desires/goals (r=0.435, p=0.030) domains of LupusPRO. A tendency was observed between sTLT-1 levels and the SLAM-R (r=-0.278, p=0.064) and the lupus symptoms (r=-0.388, p=0.055) and physical health (r=-0.382, p=0.060) domains of LupusPRO.


Conclusion
: Compared with healthy individuals, sTLT-1 levels were significantly lower in patients with SLE. Among patients with SLE, correlations were observed for some domains of LupusPRO. Given that sTLT-1 has anti-inflammatory properties, the deficiency of this protein could play an important role in the pathogenesis of SLE.


Cite this article as
: Vázquez-Otero I, Rodríguez-Navedo Y, Vilá-Rivera K, Nieves-Plaza M, Morales-Ortiz J, Washington AV, et al. Association of soluble TREM-like transcript-1 with clinical features and patient reported outcomes in systemic lupus erythematosus. Eur J Rheumatol 2018; 5: 244-8.

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