ISSN 2147-9720 | E-ISSN 2148-4279
Case Report
Paraneoplastic polyarthritis as the first manifestation of lingual carcinoma
1 Department of Rheumatology, Ramón y Cajal University Hospital, Madrid, Spain  
2 Department of Pathology, Ramón y Cajal University Hospital, Madrid, Spain  
Eur J Rheumatol ; : -
DOI: 10.5152/eurjrheum.2018.18068
Key Words: Paraneoplastic polyarthritis, paraneoplastic syndrome, tongue carcinoma, head and neck neoplasms


Paraneoplastic polyarthritis is an inflammatory arthritis, is usually seronegative, and has a temporal and pathophysiological relationship with an underlying malignancy. Although head and neck tumors may be a cause of paraneoplastic polyarthritis, its association with tongue carcinoma has not been previously reported. We present the case of a 69-year-old man who was a former smoker and presented with polyarthritis since 2 months in the wrists, proximal interphalangeal joints, knees, and elbows, with increased levels of acute-phase reactants; negativity for rheumatoid factor, anticitrullinated cyclic peptide antibody, and antinuclear antibody; and negative results for crystals and microorganisms in the synovial fluid. Cervical computed tomography and posterior rhinoscopy were performed, which detected an asymptomatic lesion on the base of the tongue, whose biopsy was compatible with nonkeratinizing squamous cell carcinoma. Polyarthritis did not respond to glucocorticoids at medium doses (oral prednisone 20 mg/day) but progressively resolved after the initiation of antineoplastic therapy.


Cite this article as: Briones-Figueroa A, Sifuentes-Giraldo WA, Carrillo-Gijón R, Morell-Hita JL. Paraneoplastic polyarthritis as the first manifestation of lingual carcinoma. Eur J Rheumatol 2018; DOI: 10.5152/eurjrheum.2018.18068

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